CAS# 70-18-8
Also Known As GSH / L-Glutathione Reduced
Sequence γ-Glu-Cys-Gly
Class Endogenous Tripeptide
Form Lyophilized Powder
Research Pathway
Research Model
Redox Pair
Glutathione (GSH; L-Glutathione reduced; CAS# 70-18-8) is an endogenous tripeptide composed of γ-glutamate, cysteine, and glycine, characterised by an unusual γ-peptide bond between the glutamate side-chain carboxyl and the cysteine amine. It is the most abundant intracellular low-molecular-weight thiol and functions as the primary endogenous redox buffer in mammalian cells. GSH is studied as a biochemical research tool for investigating oxidative stress models, Nrf2/ARE pathway activation, glutathione peroxidase and reductase enzyme kinetics, and cellular redox homeostasis. Supplied by NexPept as a lyophilized powder for in vitro laboratory research use. This compound has not been authorized by Health Canada for any therapeutic, clinical, or human use.
Molecular Profile
CAS#, sequence, formula, molecular weight, analytical data
CAS#, sequence, formula, molecular weight, analytical data
| Property | Value |
|---|---|
| CAS Number | 70-18-8 |
| Also Known As | GSH; L-Glutathione reduced; γ-L-Glutamyl-L-cysteinylglycine |
| Sequence | γ-Glu-Cys-Gly (unusual γ-peptide bond at Glu–Cys linkage) |
| Molecular Formula | C₁₀H₁₇N₃O₆S |
| Molecular Weight | 307.32 Da |
| Key Functional Group | Free thiol (–SH) on Cys residue — primary redox-active site |
| Redox Pair | GSH (reduced) / GSSG (oxidised disulfide dimer) |
| Compound Class | Endogenous tripeptide — intracellular thiol redox buffer |
| Research Pathways | Nrf2/ARE, GSH/GSSG redox ratio, GPx/GR enzyme kinetics, ROS scavenging, glutathionylation |
| Physical Form | Lyophilized powder |
| Analytical Method | High-Performance Liquid Chromatography (HPLC) + Mass Spectrometry (MS) |
| Appearance | White to off-white lyophilized solid |
In Vitro Research Context
Redox biology and antioxidant pathway research — laboratory use only
Redox biology and antioxidant pathway research — laboratory use only
Antioxidant response element transcriptional activation and Nrf2 pathway research
GSH/GSSG ratio, ROS scavenging, and intracellular thiol redox buffer characterisation
Protein S-glutathionylation, GPx/GR enzyme kinetics, and thioredoxin system studies
Glutathione (GSH) is used extensively in in vitro laboratory settings as a biochemical research reagent for investigating cellular redox biology. Research applications include GSH/GSSG ratio determination in oxidative stress models, glutathione peroxidase (GPx) and glutathione reductase (GR) enzyme activity assays, Nrf2/Keap1/ARE pathway activation studies, protein S-glutathionylation analysis, and antioxidant capacity benchmarking in cell-free systems. As the most abundant endogenous thiol, GSH is also used as a reference standard in redox proteomics workflows and as a positive control reagent in ROS scavenging assays.
Available Formats
1500mg — lyophilized powder
1500mg — lyophilized powder
| Format | Net Quantity | Physical Form |
|---|---|---|
| Glutathione 1500mg | 1500 mg / vial | Lyophilized powder |
Laboratory Storage
Controlled storage conditions for lyophilized material
Controlled storage conditions for lyophilized material
Store sealed lyophilized material under controlled laboratory conditions in accordance with validated institutional SOPs and applicable technical documentation. Protect from light, moisture, and oxidising agents. The free thiol group (–SH) on the cysteine residue is the primary redox-active site; handling conditions should be established by qualified research personnel to maintain thiol integrity in accordance with the specific experimental protocol.
Research Literature
Scientific references & related resources
Scientific references & related resources
PubMed — Glutathione / GSH Redox Research — peer-reviewed scientific literature on this compound
PubMed — Nrf2 / ARE / GSH Pathway Studies — Nrf2-Keap1 transcriptional regulation and antioxidant response element literature
Research Peptides in Canada — sourcing and research context for Canadian laboratories
What Are Research Peptides? — peptide classification and in vitro research context
This product is supplied exclusively for in vitro laboratory and non-clinical research use by qualified research personnel. It is not authorized by Health Canada for human or veterinary use. No therapeutic, clinical, or health claims are made.
This material must not be administered to humans or animals. No dosage, preparation, reconstitution, or administration instructions are provided or implied. All handling and use must be conducted by qualified personnel in accordance with applicable institutional policies and legal requirements.
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