CAS# 946870-92-4
Also Known As Long R3 IGF-1
Class Synthetic IGF-1 Analogue
Form Lyophilized Powder
Receptor Target
Peptide Length
Molecular Weight
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1, CAS# 946870-92-4) is a synthetic 83-amino acid analogue of human IGF-1, engineered with an N-terminal 13-amino acid extension and an Arg³ substitution. These modifications reduce binding affinity for IGF-binding proteins (IGFBPs), resulting in altered receptor interaction kinetics relevant to in vitro growth factor signalling research. It binds primarily to the IGF-1 receptor (IGF-1R). Supplied by NexPept as a lyophilized powder for in vitro laboratory research use. This compound has not been authorized by Health Canada for any therapeutic, clinical, or human use.
Molecular Profile
CAS#, sequence, molecular weight, structural modifications
CAS#, sequence, molecular weight, structural modifications
| Property | Value |
|---|---|
| CAS Number | 946870-92-4 |
| Common Name | Long R3 IGF-1 / LR3-IGF-1 |
| Compound Class | Synthetic IGF-1 analogue — N-terminally extended, Arg³-substituted |
| Sequence Length | 83 amino acids (vs. 70 AA in native IGF-1) |
| Molecular Weight | ~9,117 Da |
| Receptor Target | IGF-1R (Insulin-like Growth Factor 1 Receptor) |
| Key Modification | Reduced IGFBP binding affinity vs. native IGF-1 |
| Physical Form | Lyophilized powder |
| Analytical Method | High-Performance Liquid Chromatography (HPLC) + Mass Spectrometry (MS) |
| Appearance | White to off-white lyophilized solid |
In Vitro Research Context
Receptor pharmacology & signalling — laboratory use only
Receptor pharmacology & signalling — laboratory use only
A receptor tyrosine kinase that mediates downstream PI3K/AKT and MAPK/ERK signalling cascades. IGF-1 LR3 is studied for its binding at this receptor with reduced interference from IGF-binding proteins, making it a useful tool compound for controlled in vitro signalling pathway research.
IGF-1 LR3 is studied in preclinical in vitro settings as a pharmacological tool for investigating IGF-1 receptor binding, downstream signalling cascade activation, and growth factor pathway models. The reduced IGFBP binding affinity relative to native IGF-1 makes this analogue particularly suited for controlled cell culture and receptor interaction studies where IGFBP interference would otherwise confound results.
Research context: IGF-1 LR3 is an investigational synthetic peptide analogue studied in scientific research involving IGF-1R signalling and growth factor pathway models. It has not been authorized by Health Canada for human or veterinary use.
Available Formats
1mg — lyophilized powder
1mg — lyophilized powder
| Format | Net Quantity | Physical Form |
|---|---|---|
| IGF-1 LR3 1mg | 1 mg / vial | Lyophilized powder |
Sourced from a verified batch. Quantity for use should be determined based on your specific in vitro research protocol by qualified research personnel.
Laboratory Storage
Controlled storage conditions for lyophilized material
Controlled storage conditions for lyophilized material
Store sealed lyophilized material under controlled laboratory conditions in accordance with validated institutional SOPs and applicable technical documentation. Protect from light and moisture. Handling conditions should be established by qualified research personnel in accordance with the specific experimental protocol.
Note: No preparation, reconstitution, or administration instructions are provided. This compound is supplied for in vitro laboratory research use only. All handling must be conducted by qualified personnel following institutional safety protocols.
Research Literature
Scientific references & related resources
Scientific references & related resources
IGF-1 LR3 Research Peptide Overview — NexPept compound overview and in vitro research context
PubMed — IGF-1 LR3 / Long R3 IGF-1 — peer-reviewed scientific literature on this compound
Research Peptides in Canada — sourcing and research context for Canadian laboratories
What Are Research Peptides? — peptide classification and in vitro research context
This product is supplied exclusively for in vitro laboratory and non-clinical research use by qualified research personnel. It is not authorized by Health Canada for human or veterinary use. No therapeutic, clinical, or health claims are made.
This material must not be administered to humans or animals. No dosage, preparation, reconstitution, or administration instructions are provided or implied. All handling and use must be conducted by qualified personnel in accordance with applicable institutional policies and legal requirements.
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